A rare case report of conjunctival fibrolipoma in an adolescent

Fibrolipomas are a fat-containing lesions that are characterised by the presence of adipose tissue and rich amounts of fibrous tissues. We present a case of a18-year-old female presented with complaints of swelling over outer part of left eye for 2 years . Magnetic resonance imaging (MRI) revealed T1 and T2 hyperintense lesion in temporal aspect of left eyeball without any involvement of optic nerve or any hypertrophy of extra-ocular muscles. A careful dissection was done because of proximity of the lesion with lateral rectus and optic nerve, followed by excision. The diagnosis of fibrolipoma was made on histopathological examination. Fibrolipoma is a rare variant of the lipoma and only few cases have been reported in the orbit till date. The case we have reported is first of its kind in India. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)


Introduction
Lipomas are a benign variety of soft tissue neoplasms of mature adipose tissue. 1,2 A fibrolipoma is an uncommon subtype of lipomas, which are comprised of mature adipocytes. They are usually benign and nonthreatening. 3 Fibrolipomas are a member of family of fat-containing lesions that are characterised by the presence of adipose tissue and rich amounts of fibrous tissues. 4,5 They are well distinguished from the neighbouring tissues. They mostly occur in adults and only few cases have been documented worldwide. We report a case of conjunctival fibrolipoma in an 18-year-old girl, first of it's kind in India.

Case Report
An 18 year old female patient presented with a swelling over outer part of left eye for 2 years (Figure 1). Swelling became significantly prominent, with a gradual and progressive enlargement over last 6 months. It was associated with watering and foreign body sensations. There was no significant history of trauma or family history. On physical examination patient was found to have a very large tumor, approximately 2×2.3 cm in the left eye extending from upper to lower fornix with posterior border being extending about 2 cm from the anterior globe wall. It was a firm and non-tender mass, smooth and faintly lobulated, pinkish yellow in color, and soft elastic in consistency. There were no accompanying active signs of inflammation and otherwise the remaining ocular and systemic examinations were absolutely normal. Orbital MRI revealed T1 and T2 hyper-intense lesion in temporal aspect of left eyeball without any involvement of optic nerve or any hypertrophy of extra-ocular muscles ( Figure 2). A careful dissection was done because of close vicinity of lesion to optic nerve, followed by excision following which the mass was sent for histopathological examination which revealed that the lesion is composed of fibrinous collagenous tissue and sheets of mature adipose tissue without any evidence of malignancy, suggestive of fibrolipoma ( Figure 3). The cosmetic appearance of the eyelid was very satisfactory after a follow-up period of 1 year and no recurrence of tumor was observed ( Figure 4). https://doi.org/10.18231/j.ijooo.2020.033 2581-5024/© 2020 Innovative Publication, All rights reserved. 149

Discussion
Lipomas are slow growing benign tumors. They are well circumscribed and are composed of mature fat cell clustered in lobules with the help of connective tissue septa. 6 They are uncommon in the orbit, and accounts for just less than 1% of all orbital tumors. 7 Fibrolipoma is classified as a variant of lipoma by the World Health Organization (WHO), because of its composition of mature adipose tissue along with bands of dense connective tissue. 3,6,8 They are usually seen in adult men with a peak incidence in 5 th to 6 th decade of life.The age of presentation in this case was uncommon, because they are rarely observed below the age of 20 years. 6 Clinically, the patient presents with an asymptomatic, gradually growing and well circumscribed mass that can be seen in various areas, for example the oral cavity, esophagus, trachea, spermatic cord, parotid glandpharynx, larynx, colonand nose. The real incidence of fibrolipoma is hard to assess as it presents as a painless and gradual growing tumor and most commonly the patient consult clinician only for symptomatic or cosmetic problems. The consistency of fibrolipoma can be soft or firm depending on tumor depth as well as distribution of fibrous tissue. 9 There occurs a change in consistency during contraction of involved muscle, which is a characteristic of fibrolipoma. It is soft and flat during muscle relaxation and becomes firm and more spherical during contraction. 2 MRI is a useful modality for diagnosing various types of lipomas. Lipomas have high signal intensity on T1-weighted images, with relative declining signal as seen on T2weighted images, and usually the fibrolipomas are more heterogeneous as compared to lipomas on MRI imaging. The exact etiology of lipomas and their types is not well known but an association with hereditary anomalies such as origin from lipoblastic embryonic cell nest has been suggested as well as some trauma mechanisms like chronic intermittent compression or blunt trauma has also been implicated. 10 Various other causations like maturation of lipoblastomatosis, endocrinal imbalance, degenerated products of fibromatous tumor have also been cited.
Lipomas are classified on basis of their histological appearance as a simple lipoma or variant, such as angiolipoma, spindle cell, pleomorphic lipoma, myolipoma, chondroid lipoma, hibernoma and diffuse lipomatous proliferations (lipomatosis). Histologically, fibrolipomas are characterized by proliferation of components of mature adipose tissue, surrounded by septa of dense fibrous connective tissue. Furthermore, fibrolipomas have got a higher proliferative activity as compared to other variants. 9 Usually fibrolipomas are benign tumors but very rarely they can convert to liposarcoma. The clinical differential diagnosis considered for the present case includes epidermoid cyst and dermoid cyst. Histopathological examination helps in making the definitive diagnosis. The treatment of choice for fibrolipoma and its variants is complete surgical excision but it should be very precise keeping in mind not to damage any extra-ocular muscle or optic nerve lying in vicinity of the lesion. In our case the patient requested the removal of his lesion because of its growth concerns, and the cosmetic purpose. Any harm to conjunctiva should be avoided so as to prevent post-surgical symblepharon.

Conclusion
In a nutshell, fibrolipomas are a rare variant of the lipoma. The treatment of choice is excison of tumor in toto. A very careful dissection should be done keeping in mind the proximity of the lesion with other orbital structures. The histopathological examination of the excised tissue remains the gold standard for making the diagnosis because of similarity in clinical pictures of various lipomas. Fibrolipomas have got an excellent prognosis and the recurrence is very rare.

Patient consent
I certify receiving and having archived the written consentement of Miss X, who has Conjunctival fibrolipoma about potential medical press publication of her clinical observation. This report does not contain any personal identifying information.

Source of Funding
None.

Conflict of Interest
None.